Inhibition of aldehyde dehydrogenase by disulfiram and its metabolite methyl diethylthiocarbamoyl-sulfoxide

KA Veverka, KL Johnson, DC Mays, JJ Lipsky…

Index: Veverka, Karen A.; Johnson, Kenneth L.; Mays, Dennis C.; Lipsky, James J.; Naylor, Stephen Biochemical Pharmacology, 1997 , vol. 53, # 4 p. 511 - 518

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Citation Number: 41

Abstract

Disulfiram (DSF) is presently the only available drug used in the aversion therapy of recovering alcoholics. It acts by inhibiting aldehyde dehydrogenase (ALDH), leading to high blood levels of acetaldehyde. The in vitro inhibition of ALDH by DSF and its metabolites was systematically studied by combined enzyme inhibition assay with direct molecular weight determination of the same sample using electrospray ionizationmass spectrometry (ESI- ...

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