Effect of achiral support on the resolution of tetramisole by supercritical fluid extraction

E Székely, B Simándi, K László, E Fogassy…

Index: Szekely, Edit; Simandi, Bela; Laszlo, Krisztina; Fogassy, Elemer; Pokol, Gyoergy; Kmecz, Ildiko Tetrahedron Asymmetry, 2002 , vol. 13, # 13 p. 1429 - 1434

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Citation Number: 17

Abstract

The enantiomers of tetramisole were produced by partial diastereomeric salt formation with O, O′-dibenzoyl-(2R, 3R)-tartaric acid monohydrate and subsequent supercritical fluid extraction (SFE) of the unreacted enantiomers in the presence of an achiral support. The effect of the activated carbon and Perfil 100™ on the efficiency of chiral separation were studied. The kinetics of the process was found to be an important factor affecting ...