Development of dual-acting agents for thromboxane receptor antagonism and thromboxane synthase inhibition. 3. Synthesis and biological activities of …

K Takeuchi, TJ Kohn, TA True, DE Mais…

Index: Journal of Medicinal Chemistry, , vol. 41, # 27 p. 5362 - 5374

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Citation Number: 11

Abstract

... Journal of Medicinal Chemistry. ... Chemistry. As previously reported, 7 the (E)-isomer of ω-[4-[4-[(N-substituted amino)carbonyl]-2-oxazolyl]phenyl]-ω-(3-pyridyl)alkenoic acid (A) is the preferred isomer for the dual TRA/TSI activities. ...