Novel constrained CCK-B dipeptoid antagonists derived from pipecolic acid

B Bellier, S Da Nascimento, H Meudal, E Gincel…

Index: Bellier, Bruno; Da Nascimento, Sophie; Meudal, Herve; Gincel, Edith; Roques, Bernard P.; Garbay, Christiane Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 11 p. 1419 - 1424

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Citation Number: 25

Abstract

A new series of 4-substituted pipecolic acid derivatives was prepared and incorporated into dipeptoids. The resulting products behave as moderately potent CCK-B antagonists but their constrained structure and its comparison with structurally related compounds yield valuable information about the conformational requirements for optimal recognition of the CCK-B receptor by antagonists.

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