A new synthesis of aryl hetaryl ketones via SRN1 reactions of halogenated heterocycles with potassiophenylacetonitrile followed by phase??transfer catalyzed …

CKF Hermann, YP Sachdeva…

Index: Hermann, Christine K. F.; Sachdeva, Yesh P.; Wolfe, James F. Journal of Heterocyclic Chemistry, 1987 , vol. 24, p. 1061 - 1065

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Citation Number: 29

Abstract

Abstract Reaction of halogenated pyridines, quinolines, pyrimidines, and pyrazines with potassiophenylacetonitrile (5) in liquid ammonia under near-uv irradiation affords secondary nitriles, which then undergo oxidative decyanation under phase-transfer catalytic conditions to afford aryl hetaryl ketones in excellent yields.