Synthesis of Deuterated Mevalonolactone Isotopomers

…, CA Citron, NL Brock, R Riclea, H Kuhz

Index: Dickschat, Jeroen S.; Citron, Christian A.; Brock, Nelson L.; Riclea, Ramona; Kuhz, Henning European Journal of Organic Chemistry, 2011 , # 18 p. 3339 - 3346

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Citation Number: 7

Abstract

Abstract A synthetic route was developed for the preparation of deuterated mevalonolactones. Using low-cost deuterated reagents, this route allows for the independent introduction of deuterium labeling into any carbon position or into any combination of positions. Following this approach, the synthesis of [6, 6, 6-2 H 3] mevalonolactone,[4, 4, 6, 6, 6-2 H 5] mevalonolactone,[5, 5-2 H 2] mevalonolactone,[5, 5, ...