Synthesis and biological activity of peptide antagonists of luliberin (luteinizing hormone-releasing hormone)

GW Moersch, MC Rebstock, EL Wittle…

Index: Moersch,G.W. et al. Journal of Medicinal Chemistry, 1979 , vol. 22, p. 935 - 943

Full Text: HTML

Citation Number: 17

Abstract

A series of des-His2 octa-and nonapeptide analogues of luliberin (luteinizing hormone- releasing hormone) with modifications in the 1 and 6 positions, and in some instances the 10 position, has been prepared. Some of these analogues are potent inhibitors of luliberin in vitro and in vivo. The use of ultraviolet absorption measurements for evaluating peptides containing tyrosine and tryptophan is described. An efficient synthesis of 0-methyl-D- ...

Related Articles:

Asymmetric Synthesis of. alpha.-Amino Acids by Copper-Catalyzed Conjugate Addition of Grignard Reagents to Optically Active Carbamatoacrylates

[Lander, Peter A.; Hegedus, Louis S. Journal of the American Chemical Society, 1994 , vol. 116, # 18 p. 8126 - 8132]

Total structures of cryptophycins, potent antitumor depsipeptides from the blue-green alga Nostoc sp. strain GSV 224

[Trimurtulu, Golakoti; Ohtani, Ikuko; Patterson, Gregory M. L.; Moore, Richard E.; Corbett, Thomas H.; Valeriote, Frederick A.; Demchik, Lisa Journal of the American Chemical Society, 1994 , vol. 116, # 11 p. 4729 - 4737]

Asymmetric Synthesis of Unnatural Amino Acids and Tamsulosin Chiral Intermediate

[Arava, Veera Reddy; Amasa, Srinivasulu Reddy; Goud Bhatthula, Bharat Kumar; Kompella, Laxmi Srinivas; Matta, Venkata Prasad; Subha Synthetic Communications, 2013 , vol. 43, # 21 p. 2892 - 2897]

A simple and efficient diastereoselective Strecker synthesis of optically pure α-arylglycines

[Dave, Rajesh H.; Hosangadi, Bhaskar D. Tetrahedron, 1999 , vol. 55, # 37 p. 11295 - 11308]

A simple and efficient diastereoselective Strecker synthesis of optically pure α-arylglycines

[Dave, Rajesh H.; Hosangadi, Bhaskar D. Tetrahedron, 1999 , vol. 55, # 37 p. 11295 - 11308]

More Articles...