Anacardic acid derived salicylates are inhibitors or activators of lipoxygenases

R Wisastra, M Ghizzoni, A Boltjes, HJ Haisma…

Index: Wisastra, Rosalina; Ghizzoni, Massimo; Boltjes, Andre; Haisma, Hidde J.; Dekker, Frank J. Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 16 p. 5027 - 5032

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Citation Number: 17

Abstract

Lipoxygenases catalyze the oxidation of unsaturated fatty acids, such as linoleic acid, which play a crucial role in inflammatory responses. Selective inhibitors may provide a new therapeutic approach for inflammatory diseases. In this study, we describe the identification of a novel soybean lipoxygenase-1 (SLO-1) inhibitor and a potato 5-lipoxygenase (5-LOX) activator from a screening of a focused compound collection around the natural product ...