Regioselectivity in the Aryne Cross??Coupling of Aryllithiums with Functionalized 1, 2??Dibromobenzenes

…, M Begaud, FR Leroux, F Colobert

Index: Diemer, Vincent; Begaud, Manon; Leroux, Frederic R.; Colobert, Fracoise European Journal of Organic Chemistry, 2011 , # 2 p. 341 - 354

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Citation Number: 11

Abstract

Abstract Tri-and tetrasubstituted ortho-bromobiaryls have been synthesized in good-to- excellent yields by aryne cross-coupling reactions starting from 1, 3-dimethoxybenzene and functionalized 1, 2-dibromobenzenes. This study outlines the influence of the 1, 2- dibromobenzene precursor as well as the reaction temperature on the outcome of the aryl– aryl bond formation and indicates, in the case of dissymmetrical benzyne precursors, how ...

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