Journal of Fluorine Chemistry

Aromatic fluorine chemistry. Part 5. Preparation of 2, 6-difluoroaniline and 1, 2-difluorobenzene

RG Pews, JA Gall

Index: Pews, R. Garth; Gall, James A. Journal of Fluorine Chemistry, 1991 , vol. 53, # 3 p. 379 - 386

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Citation Number: 4

Abstract

Abstract The preparation of 2, 6-difluoroaniline and 1, 2-difluorobenzene from 1, 2, 3- trichlorobenzene is described. An isomeric mixture of 1-chloro-2, 3-difluorobenzene and 2- chloro-1, 3-difluorobenzene is obtained from KF exchange on 1, 2, 3-trichlorobenzene. Selective dechlorination of 1-chloro-2, 3-difluorobenzene with H 2 and Pd/C catalyst gives 1, 2-difluorobenzene. 2, 6-Difluoroaniline is obtained via ammonolysis of 2-chloro-1, 3- ...