Synthesis of an orally active PAF antagonist of the N-[4-(3-pyridinyl) butyl] pentadienamide class

…, A Schwartz, S Wolff, PS Belica, P MADAN, P PATEL…

Index: Manchand, Percy S.; Schwartz, Alan; Wolff, Steven; Belica, Peter S.; Madan, Pradeep; et al. Heterocycles, 1993 , vol. 35, # 2 p. 1351 - 1369

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Citation Number: 10

Abstract

Résumé/Abstract The PAF antagonist [R-(E, E)]-5-(4-methoxyphenyl)-N-[1-methyl-4-(3- pyridinyl) butyl]-2, 4-decadienamide (2) was synthesized from (S)-α-methyl-3- pyridinebutanol (14), which was obtained either from ethyl lactate or by enantioselective kinetic hydrolysis of its racemate using the lipase derived from Pseudomonaas cepacia (syn. P. fluorescens). Mesylation of 14, followed by azide displacement and hydrogenation, ...