Synthesis of [trifluoromethyl??[14C6]??phenyl]??SR 57746A

N Robic, JP Noël

Index: Robic; Noel Journal of Labelled Compounds and Radiopharmaceuticals, 1999 , vol. 42, # 2 p. 109 - 119

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Abstract

Abstract [Trifluoromethyl-[14 C 6]-phenyl]-SR 57746A 4, a neurotrophic and neuroprotective compound, has been synthesized for metabolic and pharmacokinetic studies. The key step for its synthesis was the preparation of 3-trifluoromethyl-[14 C 6]-bromobenzene 1. This compound was obtained in 4 steps from [14 C 6]-nitrobenzene 10 via [14 C 6]-3-iodo- nitrobenzene 11, 3-trifluoromethyl-[14 C 6]-nitrobenzene 8, 3-trifluoromethyl-[14 C 6]- ...