Antagonists of the calcium receptor. 2. Amino alcohol-based parathyroid hormone secretagogues

…, GB Stroup, S Hoffman, M Gowen, EG DelMar…

Index: Marquis, Robert W.; Lago, Amparo M.; Callahan, James F.; Rahman, Attiq; Dong, Xiaoyang; Stroup, George B.; Hoffman, Sandra; Gowen, Maxine; DelMar, Eric G.; Van Wagenen, Bradford C.; Logan, Sarah; Shimizu, Scott; Fox, John; Nemeth, Edward F.; Roethke, Theresa; Smith, Brian R.; Ward, Keith W.; Bhatnagar, Pradip Journal of Medicinal Chemistry, 2009 , vol. 52, # 21 p. 6599 - 6605

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Citation Number: 16

Abstract

When administered as a single agent to rats, the previously reported calcium receptor antagonist 3 elicited a sustained elevation of plasma PTH resulting in no increase in overall bone mineral density. The lack of a bone building effect for analogue 3 was attributed to the large volume of distribution (Vdss (rat)= 11 L/kg), producing a protracted plasma PTH profile. Incorporation of a carboxylic acid functionality into the amino alcohol template led to the ...