Synthesis and biological evaluation of novel 99mTc-labelled bisphosphonates as superior bone imaging agents

L Qiu, W Cheng, J Lin, S Luo, L Xue, J Pan

Index: Qiu, Ling; Cheng, Wen; Lin, Jianguo; Luo, Shineng; Xue, Li; Pan, Jing Molecules, 2011 , vol. 16, # 8 p. 6165 - 6178

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Citation Number: 18

Abstract

Abstract A series of novel zoledronic acid (ZL) derivatives 1-hydroxy-3-(2-methyl-1H- imidazol-1-yl) propane-1, 1-diyldiphosphonic acid (MIPrDP), 1-hydroxy-4-(2-methyl-1H- imidazol-1-yl) butane-1, 1-diyldiphosphonic acid (MIBDP), and 1-hydroxy-5-(2-methyl-1H- imidazol-1-yl) pentane-1, 1-diyldiphosphonic acid (MIPeDP) were prepared and successfully labeled with 99m Tc in high labeling yields. The in vitro stability and in vivo ...