Reactions of N-aminopyrazoles with halogenating reagents and synthesis of 1, 2, 3-triazines.

…, T KAIHOH, T ITOH, M OKADA, C KAWABATA…

Index: Ohsawa, Akio; Kaihoh, Terumitsu; Itoh, Takashi; Okada, Mamiko; Kawabata, Chikako; et al. Chemical & Pharmaceutical Bulletin, 1988 , vol. 36, # 10 p. 3838 - 3848

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Citation Number: 20

Abstract

Reactions of N-aminopyrazoles with halogenating reagents (Cl 2, Br 2, I 2, BrCl, ICl, IBr, N- chlorosuccinimide, and N-bromosuccinimide) were examined. Some of these reagents preferentially lead to oxidation of the amino group to give the corresponding 1, 2, 3-triazines as major products, while others mainly gave either or both of 1-amino-4-halopyrazoles and 5- halo-1, 2, 3-triazines as the result of halogenation of the 4-position of the pyrazole ring ...