Conformationally restricted inhibitors of angiotensin-converting enzyme. Synthesis and computations

…, SD Aster, ER Peterson, JP Snyder…

Index: Thorsett, Eugene D.; Harris, Elbert E.; Aster, Susan D.; Peterson, Elwood R.; Snyder, James P.; et al. Journal of Medicinal Chemistry, 1986 , vol. 29, # 2 p. 251 - 260

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Citation Number: 118

Abstract

A series of inhibitors of angiotensin converting enzyme (ACE, dipeptidyl carboxypeptidase, EC 3.4. 15.1) is described which addresses certain conformational aspects of the enzyme- inhibitor interaction. In this study the alanylproline portion of the potent ACE inhibitor enalaprilat (2) is replaced by a aeries of monocyclic ladams containing the required recognition and binding elements. In order to more fully assess the lactam ring ...