Synthesis and biological evaluation of cycloalkylidene carboxylic acids as novel effectors of Ras/Raf interaction

…, K Hell-Momeni, I Zündorf, T Winckler…

Index: Friese, Anke; Hell-Momeni, Katja; Zuendorf, Ilse; Winckler, Thomas; Dingermann, Theodor; Dannhardt, Gerd Journal of Medicinal Chemistry, 2002 , vol. 45, # 7 p. 1535 - 1542

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Citation Number: 15

Abstract

The protooncogenes Ras and Raf play important roles in signal transduction pathways regulated by mitogen-activated protein kinases. Mutations of Ras that arrest the protein in its active state are frequently implicated in tumor formation. We used Ras and Raf proteins in the yeast two-hybrid system to search for natural or synthesized substances capable of modulating Ras/Raf interaction by specifically binding to one of the interacting partners. ...

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