8-Anilinoimidazo [4, 5-g] quinoline-7-carbonitriles as Src kinase inhibitors

…, M Dutia, D Powell, B Wu, A Wissner, F DeMorin…

Index: Berger, Dan; Dutia, Minu; Powell, Dennis; Wu, Biqi; Wissner, Allan; DeMorin, Frenel; Weber, Jennifer; Boschelli, Frank Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 19 p. 2761 - 2765

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Citation Number: 16

Abstract

A series of 8-anilinoimidazo [4, 5-g] quinoline-7-carbonitriles was synthesized and evaluated as Src kinase inhibitors. Several aniline substituents were surveyed, as well as water-solubilizing groups at the C-2 and N-3 positions. Potent Src inhibitors were identified, with N-3 providing the best position for an additional water-solubilizing group.