Chemical Communications

Investigation of glycerol incorporation into soraphen A

AM Hill, JP Harris, AP Siskos

Index: Hill, Alison M.; Harris, Jonathan P.; Siskos, Alexandros P. Chemical Communications, 1998 , # 21 p. 2361 - 2362

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Citation Number: 14

Abstract

Glycerol has been incorporated mid-chain into the polyketide soraphen A 1 at C-3, 4 and C- 11, 12; the pro-(S)-hydroxymethyl group of glycerol is lost and one of the hydrogens in the pro-(R)-hydroxymethyl group is retained at C-11 which excludes hydroxymalonate as the immediate precursor to the vicinal methoxy groups at C-11, 12.

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