Esters of isoguvacine as potential prodrugs

E Falch, P Krogsgaard-Larsen…

Index: Falch, Erik; Krogsgaard-Larsen, Povl Journal of Medicinal Chemistry, 1981 , vol. 24, # 3 p. 285 - 289

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Citation Number: 11

Abstract

The syntheses of the methyl ester, butyl ester,(ethoxycarbony1) methyl ester, and 11 (acy1oxy) methyl esters of the potent y-aminobutyric acid agonist isoguvacine (1, 2, 3, 6- tetrahydropyidine-4-carboxylic acid) are described. The chemical stability of the esters and their in vitro rates of hydrolysis under approximately physiological conditions by nonspecific eaterases from human serum were examined. A selected number of the eaters were ...