3??Formylpyrroles from 3??Furfurylamines by Bromine Oxidation Reaction

PJ Harn, CC Lin, HJ Wu

Index: Harn, Piin-Jye; Lin, Chu-Chung; Wu, Hsien-Jen Journal of the Chinese Chemical Society, 2010 , vol. 57, # 6 p. 1321 - 1326

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Abstract

Abstract Oxidation of 3-furfurylamines 3a-e with bromine in acetone-water solution gave N- substituted 3-formylpyrroles 4a-e in good yields. A reaction mechanism via the Clauson- Kaas reaction followed by the cis-trans isomerization of the 2-ene-1, 4-diones 13 and 14 was proposed to account for the formation of the pyrroles 4a-e.