Synthetic Communications®

Convenient Synthesis of N-Hydroxysuccinimide Esters from Carboxylic Acids Using Triphosgene

M Kim, KJ Han

Index: Kim, Misoo; Han, Ki-Jong Synthetic Communications, 2009 , vol. 39, # 24 p. 4467 - 4472

Full Text: HTML

Citation Number: 7

Abstract

Abstract A simple and convenient method for the synthesis of N-hydroxysuccinimide ester is developed using triphosgene as an acid activator. Several aromatic and aliphatic N- hydroxysuccinimide esters are prepared from their corresponding carboxylic acids at room

Related Articles:

Preparation of N-hydroxysuccinimido esters via palladium-catalyzed carbonylation of aryl triflates and halides

[Lou, Rongliang; VanAlstine, Melissa; Sun, Xufeng; Wentland, Mark P. Tetrahedron Letters, 2003 , vol. 44, # 12 p. 2477 - 2480]

N-hydroxysuccinimide-promoted oxidation of primary alcohols and aldehydes to form active esters with hypervalent (III) iodine

[Wang, Naiwei; Liu, Renhua; Xu, Qing; Liang, Xinmiao Chemistry Letters, 2006 , vol. 35, # 6 p. 566 - 567]

Synthesis of procainamide metabolites. N-acetyl desethylprocainamide and desethylprocainamide

[Adamczyk, Maciej; Fino, James R. Organic Preparations and Procedures International, 1996 , vol. 28, # 4 p. 470 - 474]

More Articles...