Synthesis of procainamide metabolites. N-acetyl desethylprocainamide and desethylprocainamide

M Adamczyk, JR Fino

Index: Adamczyk, Maciej; Fino, James R. Organic Preparations and Procedures International, 1996 , vol. 28, # 4 p. 470 - 474

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Citation Number: 17

Abstract

Several preparations of DEPA (2b) have been reported. One route employed the direct acylation of N-ethylethylenedihe with p-nitrobenzoyl chloride followed by reduction of the nitro group: In our hands, this acylation was not selective, leading to a complex mixture which was difficult to purify. The same group reported a second route to 2b which entailed acylation of N-ethylethylenediamine with N-Cbz-protected p-aminobenzoic acid NHS ...

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