Synthesis of Free NH 2??(Aminomethyl) indoles through Copper??Catalyzed Reaction of 3??(ortho??Trifluoroacetamidophenyl)??1??propargylic Alcohols with Amines and …

…, R Verdiglione, A Goggiamani

Index: Cacchi, Sandro; Fabrizi, Giancarlo; Goggiamani, Antonella; Molinaro, Carmela; Verdiglione, Rosanna Journal of Organic Chemistry, 2014 , vol. 79, # 1 p. 401 - 407

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Abstract

Abstract: Free NH 2-(aminomethyl) indoles have been prepared via copper-catalyzed cyclization of 3-(ortho-trifluoroacetamidophenyl)-1-propargylic alcohols in the presence of primary or secondary amines. The synthesis has been developed into a simple and very efficient domino three-component Sonogashira cross-coupling/cyclization/substitution process that, omitting the isolation of 3-(ortho-trifluoroacetamidophenyl)-1-propargylic ...

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