Bioorganic & medicinal chemistry

The synthesis and evaluation of flavone and isoflavone chimeras of novobiocin and derrubone

JR Mays, SA Hill, JT Moyers, BSJ Blagg

Index: Mays, Jared R.; Hill, Stephanie A.; Moyers, Justin T.; Blagg, Brian S.J. Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 1 p. 249 - 266

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Citation Number: 16

Abstract

The natural products novobiocin and derrubone have both demonstrated Hsp90 inhibition and structure–activity relationships have been established for each scaffold. Given these compounds share several key structural features, we hypothesized that incorporation of elements from each could provide insight to structural features important for Hsp90 inhibition. Thus, chimeric analogues of novobiocin and derrubone were constructed and ...