Tetrahedron letters

Approaches to the synthesis of ureapeptoid peptidomimetics

JAW Kruijtzer, DJ Lefeber, RMJ Liskamp

Index: Kruijtzer, John A. W.; Lefeber, Dirk J.; Liskamp, Rob M. J. Tetrahedron Letters, 1997 , vol. 38, # 30 p. 5335 - 5338

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Citation Number: 85

Abstract

ureapeptoid peptidomimetics can be composed from Boc-protected N-substituted ethylenediamines. The best approach is to synthesize these from chloroacetonitrile followed by conversion to the corresponding crystalline p-nitrophenyl carbamates in order to prepare the ureapeptoids.

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