Synthesis of a PNA-encoded cysteine protease inhibitor library

F Debaene, L Mejias, JL Harris, N Winssinger

Index: Debaene, Francois; Mejias, Lorenzo; Harris, Jennifer L.; Winssinger, Nicolas Tetrahedron, 2004 , vol. 60, # 39 p. 8677 - 8690

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Citation Number: 36

Abstract

Peptide nucleic acids (PNAs) have been used to encode a combinatorial library whereby each compound is labeled with a PNA tag which reflects its synthetic history and localizes the compound upon hybridization to an oligonucleotide array. We report herein the full synthetic details for a 4000 member PNA-encoded library targeted towards cysteine protease.