Asymmetric synthesis. Metal complex mediated synthesis of chiral glycine by enantioselective proton exchange

…, JF Sawyer, J Whelan, B Bosnich

Index: Dokuzovic, Zdravko; Roberts, Nicholas K.; Sawyer, Jeffery F.; Whelan, John; Bosnich, B. Journal of the American Chemical Society, 1986 , vol. 108, # 8 p. 2034 - 2039

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Citation Number: 38

Abstract

Abstract: The complex [Co ((S, S)-proam)(picgly)]+, a species containing a chiral tridentate triamine ligand,(S, S)-proam, and a tridentate ligand incorporating a glycine residue, picgly, has been prepared. The a-protons of the coordinated glycine residue exchange at different rates in basic D 2 0 solutions. The difference in rate was found to be 7.8: l in favor of the pro3 proton at pD 11.2 at 25 OC with a NaHC03/Na2C03 buffer. It is proposed that the origins ...

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