Caffeic acid derivatives: a new type of influenza neuraminidase inhibitors

Y Xie, B Huang, K Yu, F Shi, T Liu, W Xu

Index: Xie, Yuanchao; Huang, Bing; Yu, Kexiang; Shi, Fangyuan; Liu, Tianqi; Xu, Wenfang Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 12 p. 3556 - 3560

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Citation Number: 17

Abstract

Recently, many natural products, especially some plant-derived polyphenols have been found to exert antiviral effects against influenza virus and show inhibitory activities on neuraminidases (NAs). In our research, we took caffeic acid which contained two phenolic hydroxyl groups as the basic fragment to build a small compound library with various structures. The enzyme inhibition result indicated that some compounds exhibited ...

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