Discovery of an HIV integrase inhibitor with an excellent resistance profile

DC Pryde, R Webster, SL Butler, EJ Murray…

Index: MedChemComm, , vol. 4, # 4 p. 709 - 719

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Citation Number: 6

Abstract

... 6 mL min −1 kg −1 ), volume of distribution was estimated assuming that volume of distribution ... 22.5 mM MOPS (pH 7.2), 20 mM NaCl, 4 mM CHAPS, 0.05% NP40, 4 mM MgCl 2 ... The corrected percentage inhibition for a compound was fit to a four-parameter logistic equation with ...