Synthesis of 6-alkynylated uridines

H Tanaka, K Haraguchi, Y Koizumi…

Index: Tanaka, Hiromichi; Haraguchi, Kazuhiro; Koizumi, Yachiyo; Fukui, Mariko; Miyasaka, Tadashi Canadian Journal of Chemistry, 1986 , vol. 64, p. 1560 - 1563

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Citation Number: 15

Abstract

6-Alkynylated uridines, a hitherto unknown class of compounds, were synthesized by a coupling reaction of terminal alkynes with 6-iodo-2', 3'-O-isopropylidene-5'-O- methoxymethyluridine in the presence of bis (triphenylphosphine) palladium (II) chloride and copper (I) iodide. 6-Ethynyl-2'-deoxyuridine was also prepared by using 6-iodo-3', 5'-O-( tetraisopropyldisiloxan-1, 3-diyl)-2'-deoxyuridine as a starting material.

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