Antihistamine substances. LIII. ortho-Substituted derivatives of 1, 1-diphenyl-1-(2-dimethylaminoethoxy) ethane

V Seidlova, L Novák, JO Jílek, J Metyš…

Index: Seidlova,V. et al. Collection of Czechoslovak Chemical Communications, 1971 , vol. 36, p. 299 - 303

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Abstract

Some time agol we described the synthesis of a series of p-and m· substituted derivatives of 1, 1-diphenyl-l-(2-dimethylaminoethoxy) ethane (" mephenhydramine", I), particularly the p- halogen derivatives of which. proved to be highly active antihistaminics2• 3• Literature data4• 5 on the anticholinergic activity of o-methylbenzhydryl 2-dimethylaminoethyl ether (" orphenadrine", VII) attracted the attention to the hitherto unknown o-substituted derivatives ...