Steroids

Facile radiosynthesis of new carbon-11-labeled propanamide derivatives as selective androgen receptor modulator (SARM) radioligands for prostate cancer imaging

M Gao, M Wang, KD Miller, QH Zheng

Index: Gao, Mingzhang; Wang, Min; Miller, Kathy D.; Zheng, Qi-Huang Steroids, 2011 , vol. 76, # 13 p. 1505 - 1512

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Citation Number: 3

Abstract

The androgen receptor (AR) is an attractive target for the treatment and molecular imaging of prostate cancer. New carbon-11-labeled propanamide derivatives were first designed and synthesized as selective androgen receptor modulator (SARM) radioligands for prostate cancer imaging using the biomedical imaging technique positron emission tomography (PET). The target tracers,(S)-N-(4-cyano-3-(trifluoromethyl) phenyl)-2-hydroxy-3-(2-[11C] ...