Development of a scaleable synthesis of a 3-aminopyrazinone acetamide thrombin inhibitor
MS Ashwood, RJ Alabaster, IF Cottrell…
Index: Organic Process Research and Development, , vol. 8, # 2 p. 192 - 200
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Abstract
... Organic Process Research & Development. ... The use of low-temperature reactions, fluorinating agents, and sodium azide had all been removed from the process. ... Following this procedure, glycine ethyl ester 21 was acylated with ethyl oxalyl chloride 20 (2.0 equiv) at 0 °C under ...
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[Ashwood, Michael S.; Alabaster, Ramon J.; Cottrell, Ian F.; Cowden, Cameron J.; Davies, Antony J.; Dolling, Ulf H.; Emerson, Khateeta M.; Gibb, Andrew D.; Hands, David; Wallace, Debra J.; Wilson, Robert D. Organic Process Research and Development, 2004 , vol. 8, # 2 p. 192 - 200]
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