Preparation of Chlorotrimethylsilyl Enol Ethers from α-Chloroketones Using Trimethylsilyl Iodide

RD Miller, DR McKean

Index: Miller, R. D.; McKean, D. R. Synthetic Communications, 1982 , vol. 12, # 4 p. 319 - 322

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Citation Number: 13

Abstract

Recent literature reports of the facile hydrodehalogenation of a variety of a-haloketones by trimethylsilyl iodide (TMiI) used either as the preformed reagent or generated in situ prompts us to report our results in this area. We have been studying mild techniques which can be employed for the generation of trirnethylsilyl enol ethers from a-hnloketones, in particular, those procedures which result in thermodynamically equilibrated products. In this regard, ...