α-Tetralone derivatives as inhibitors of monoamine oxidase

LJ Legoabe, A Petzer, JP Petzer

Index: Legoabe, Lesetja J.; Petzer, Anel; Petzer, Jacobus P. Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 12 p. 2758 - 2763

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Citation Number: 17

Abstract

Abstract In the present study, a series of fifteen α-tetralone (3, 4-dihydro-2H-naphthalen-1- one) derivatives were synthesised and evaluated as inhibitors of recombinant human monoamine oxidase (MAO) A and B. The α-tetralone derivatives examined are structurally related to a series of chromone (1-benzopyran-4-one) derivatives which has previously been shown to act as MAO-B inhibitors. The results document that the α-tetralones are ...