Lipase-catalysed N-acylation of β 2-amino esters

M Fitz, E Forró, E Vigóczki, L Lázár, F Fülöp

Index: Fitz, Monika; Forro, Eniko; Vigoczki, Edina; Lazar, Laszlo; Fueloep, Ferenc Tetrahedron Asymmetry, 2008 , vol. 19, # 9 p. 1114 - 1119

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Citation Number: 17

Abstract

The Candida antarctica lipase A-catalysed N-acylation of ethyl 3-amino-2-ethylpropanoate rac-3 and methyl 3-amino-2-isopropylpropanoate rac-6 was performed with ethyl butanoate in tert-amyl alcohol at 4° C. The resulting enantiomerically enriched derivatives were isolated as N-Boc-protected amino esters (R)-9 and (R)-10 and butyramides (S)-7 and (S)-8 (ee: 76–95%).