Tetrahedron letters

The biosynthesis of ubiquinone: synthesis and enzymatic modification of biosynthetic precursors

JA Shepherd, WW Poon, DC Myles, CF Clarke

Index: Shepherd, Jennifer A.; Poon, Wayne W.; Myles, David C.; Clarke, Catherine F. Tetrahedron Letters, 1996 , vol. 37, # 14 p. 2395 - 2398

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Citation Number: 24

Abstract

The synthesis of key intermediates in the eukaryotic biosynthetic pathway of ubiquinone (Q) and the biotransformation of these materials with yeast (S. cerevisiae) mitochondria are described. The synthesis of Q aromatic precursors 2, 3, and 4 (n= 3 in all cases) relies on the palladium (O) catalyzed coupling of farnesyl tributylstannane with suitably functionalized aryl halides. Preliminary experiments show that incubation of synthetic substrate 3 with ...