Tetrahedron letters

An efficient synthesis of phenanthro-fused thiazoles by a non-phenolic oxidative coupling procedure of 4, 5-diarylthiazoles

I Moreno, I Tellitu, R SanMartin, D Badia, L Carrillo…

Index: Moreno; Tellitu; SanMartin; Badia; Carrillo; Dominguez Tetrahedron Letters, 1999 , vol. 40, # 27 p. 5067 - 5070

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Citation Number: 19

Abstract

A concise synthesis of the title compounds 6 is accomplished in high overall yield in a two step process starting from bromoketone 4. A thiazole ring formation and a non-phenolic oxidative coupling reaction using PIFA are features of the described synthesis. An exploration of the electronic requirements and the regioselectivity of the cyclization is also presented.