Tetrahedron Letters

A convenient approach for the synthesis of 2, 6-diformyl-and 2, 6-diacetylpyridines

PV Ivchenko, IE Nifant'ev, IV Buslov

Index: Ivchenko, Pavel V.; Nifant'Ev, Ilya E.; Buslov, Ivan V. Tetrahedron Letters, 2013 , vol. 54, # 3 p. 217 - 219

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Citation Number: 4

Abstract

2, 6-Diformyl-and 2, 6-diacetylpyridines are readily accessed in good yields (60–90%) via the single-pot reaction of 2, 6-pyridine dicarboxamides with LiAlH4 or MeMgCl in THF at 0– 20° C. The high efficiency of the method illustrates the significance of solubility in the reduction and alkylation of difunctionalized substrates.