Highly Diastereoselective One??Pot Synthesis of Spirocyclic Oxindoles through Intramolecular Ullmann Coupling and Claisen Rearrangement

…, Y Okawa, A Nakazaki, S Kobayashi

Index: Miyamoto, Hiroshi; Okawa, Yoichiro; Nakazaki, Atsuo; Kobayashi, Susumu Angewandte Chemie - International Edition, 2006 , vol. 45, # 14 p. 2274 - 2277

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Citation Number: 86

Abstract

Oxindoles that incorporate a quaternary stereogenic center at C3 are attractive targets in organic synthesis because of their significant biological activities as well as wide-ranging utility as synthetic intermediates for alkaloids, drug candidates, and clinical pharmaceuticals.[1] Therefore, a number of synthetic methods have been developed in pursuit of this structure, including intermolecular alkylations,[2] palladium-catalyzed ...