Journal of the American Chemical Society

Pyridines. V. The Japp--Klingemann Reaction Applied to 2-Pyridylacetic Acids

RL Frank, RR Phillips

Index: Frank; Phillips Journal of the American Chemical Society, 1949 , vol. 71, p. 2804

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Citation Number: 8

Abstract

Extension of this reaction for the formation of aryl hydrazones of higher homologs of 2- formylpyridine presented the problem of preparation of substituted 2-pyridylacetic acids or their derivatives. Ethyl 2-pyridylacetate (I) is obtainable in 35-409; d yield by carbonation of 2- picolyllithium followed by esterification, 6 but application of this method to the ethylpyridyl homolog (11) gave only traces of impure product.