Molecular structures of new ciprofloxacin derivatives

…, N Kujundžić, MB Krajačić, A Višnjevac…

Index: Tomisic, Zrinka Banic; Kujundzic, Nedjeljko; Krajacic, Mirjana Bukvic; Visnjevac, Aleksandar; Kojic-Prodic, Biserka Journal of Molecular Structure, 2002 , vol. 611, # 1-3 p. 73 - 81

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Citation Number: 8

Abstract

Two new derivatives from the ciprofloxacin fluoroquinoline family, 7-chloro-1-cyclopropyl-6- fluoro-1, 4-dihydro-4-oxo-quinoline-3-methylcarbamate and 1-cyclopropyl-7-(4-ethyl-1- piperazinyl)-6-fluoro-1, 4-dihydro-(3-oxopyrazolo)[4, 3-c] quinoline, were synthesised, tested for antibacterial activity and crystallised. Their molecular and crystal structures were determined. Tests in vitro reveal lower activities than for ciprofloxacin. Characteristic ...