Chiral interactions of the fluoroether anesthetics desflurane, isoflurane, enflurane, and analogues with modified cyclodextrins studied by capillary gas chromatography …

K Ramig, A Krishnaswami, LA Rozov

Index: Ramig, Keith; Krishnaswami, Ashok; Rozov, Leonid A. Tetrahedron, 1996 , vol. 52, # 1 p. 319 - 330

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Citation Number: 15

Abstract

Eighteen chiral analogues of the chiral fluoroether anesthetics desflurane, isoflurane, and enflurane are synthesized and studied by capillary GC on four cyclodextrin-derived stationary phases. Trends in separability and elution order of enantiomers are related to structure and absolute configuration. In particular, a very large separation factor is found for the commercial anesthetic desflurane using Lipodex® E stationary phase, suggesting that ...