Novel, potent, and selective phosphodiesterase 5 inhibitors: synthesis and biological activities of a series of 4-aryl-1-isoquinolinone derivatives

…, J Kotera, M Takagi, K Kikkawa…

Index: Iwasaki, Tameo; Kondo, Kazuhiko; Kuroda, Tooru; Moritani, Yasunori; Yamagata, Shinsuke; Sugiura, Masaki; Kikkawa, Hideo; Kaminuma, Osamu; Ikezawa, Katsuo Journal of Medicinal Chemistry, 1996 , vol. 39, # 14 p. 2696 - 2704

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Citation Number: 59

Abstract

A novel class of potent and selective phosphodiesterase 5 (PDE5) inhibitors, 4-aryl-1- isoquinolinone derivatives, which have been designed by the comparison of the structure of cGMP and a previously reported 1-arylnaphthalene lignan, was disclosed. Among these