Identification of 2, 3, 6-trisubstituted quinoxaline derivatives as a Wnt2/β-catenin pathway inhibitor in non-small-cell lung cancer cell lines

SB Lee, YI Park, MS Dong, YD Gong

Index: Lee, Sang-Bum; Park, Young In; Dong, Mi-Sook; Gong, Young-Dae Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 19 p. 5900 - 5904

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Citation Number: 25

Abstract

We screened 1434 small heterocyclic molecules and identified thirteen 2, 3, 6-trisubstituted quinoxaline derivatives that were able to inhibit the Wnt/β-catenin signal pathway and cell proliferation. In the screen, some of the hit compounds such as the ethylene group-coupled quinoxaline derivatives were shown to hold promise for use as potential small-molecule inhibitors of the Wnt/β-catenin signal pathway in non-small-cell lung cancer cell lines.