NMR evaluation of interactions between substituted-indole and PDZ1 domain of PSD-95

…, B Boucherle, H Deokar, I Thomas, I Ripoche…

Index: Vogrig, Alexandre; Boucherle, Benjamin; Deokar, Hemantkumar; Thomas, Isabelle; Ripoche, Isabelle; Lian, Lu-Yun; Ducki, Sylvie Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 11 p. 3349 - 3353

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Citation Number: 6

Abstract

Abstract We synthesized small organic molecules designed as PDZ ligands. These indole- based compounds were evaluated for their interaction with the PDZ1 domain of the post- synaptic density 95 (PSD-95) protein. Three molecules were found to interact with the targeted PDZ protein by NMR. One of them showed chemical shift perturbations closely related to the natural ligands.

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