An improved synthesis of ethyl 5-chloro-4-fluoro-1 H-indole-2-carboxylate

F Piscitelli, GL Regina, R Silvestri

Index: Piscitelli, Francesco; La Regina, Giuseppe; Silvestri, Romano Organic Preparations and Procedures International, 2008 , vol. 40, # 2 p. 204 - 208

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Citation Number: 4

Abstract

The latter six-steps procedure provided 2 in 37% overall yield starting from the commercially available aniline 6 (the overall yield with the older proedureZ was only 5%). In addition, it is faster because it avoides tedious repeated chromatographies needed for the separation of the isomers. The procedure described in Scheme 2 is a major improvement in the synthesis of 2 in 37% overall yield from 6.