Tetrahedron

Indium trichloride catalyzed one-step synthesis of α-amino nitriles by a three-component condensation of carbonyl compounds, amines and potassium cyanide

BC Ranu, SS Dey, A Hajra

Index: Ranu, Brindaban C; Dey, Suvendu S; Hajra, Alakananda Tetrahedron, 2002 , vol. 58, # 13 p. 2529 - 2532

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Citation Number: 118

Abstract

The synthesis of α-amino nitriles has been the subject of considerable current interest as these molecules serve as useful intermediates towards preparation of α-amino acids. 1 The classical procedure, known as the Strecker reaction for their synthesis involves the treatment of an aldehyde or a ketone with alkaline cyanides and salts of amines, and was discovered a century and a half ago. 2 The reaction is usually carried out in aqueous solution and the work-up procedure ...

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