5-Amidinobenzo [b] thiophenes as dual inhibitors of factors IXa and Xa

JX Qiao, X Cheng, DP Modi, KA Rossi…

Index: Bioorganic and Medicinal Chemistry Letters, , vol. 15, # 1 p. 29 - 35

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Citation Number: 52

Abstract

... Bioorganic & Medicinal Chemistry Letters. ... Alkylation of 5a or 5b with benzyl bromide led to the corresponding ester 6a or 6b, which was then hydrolyzed to give the acid 7. Coupling of 7 with aniline 8 followed by Pinner chemistry/ammonolysis afforded 3. Alternatively, the acid ...